Boutet, Marie-Astrid

Postdoctoral Research Fellow

Summary of Research

Investigation of Interleukin(IL)-36 and IL-38 expression and role in Rheumatoid Arthritis and Psoriatic Arthritis. 

Key Publications

Boutet MA, Najm A,Bart G, Brion R, Touchais S, Trichet V, Layrolle P, Gabay C, Palmer G, Blanchard F and Le Goff B. (2017) IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis. Doi: 10.1136/annrheumdis-2016-210630, in press.

Boutet MA, Bart G, Gahier M, Amiaud J, Brulin B, Charrier C, Morel F, Lecron JC, Rolli Derkinderen M, Boureille A, Vigne S, Gabay C, Palmer G, Le Goff B, Blanchard F. (2016) Distinct expression of IL-36α, β, γ and their antagonists IL-36Ra and IL-38 in Psoriasis, Rheumatoid Arthritis and Crohn’s disease. Clin Exp Immunol. doi: 10.1111/cei.12761.

Arshad MI, Guihard P, Danger Y, Noel G, Le Seyec J, Boutet MA, Richards CD, L'Helgoualc'h A, Genet V, Lucas-Clerc C, Gascan H, Blanchard F, Piquet-Pellorce C, Samson M. (2015) Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2+CD4+ lymphocytes. Am J Physiol Gastrointest Liver Physiol, 309:G542-53.

Bougault C, Briolay A, Boutet MA, Pilet P, Delplace S, Le Goff B, Guicheux J, Blanchard F, Magne D. (2015) Wnt5a is expressed in spondyloarthritis and exerts opposite effects on enthesis and bone in murine organ and cell cultures. Transl Res, 166:627-38.

Rabeony H, Pohin M, Vasseur P, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F. (2015) IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol, 45:2847-2857.

Guihard P*, Boutet MA*, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F. (2015) Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 185:765-75.

* Equal contribution

Darrieutort-Laffite C, Boutet MA, Chatelais M, Brion R, Blanchard F, Heymann D, Le Goff B. (2014) IL-1β and TNFα promote monocyte viability through the induction of GM-CSF expression by rheumatoid arthritis synovial fibroblasts. Mediators Inflamm: 241840.


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