Thorborn, Georgina

Postdoctoral Research Fellow

Key Publications

Georgina Thorborn, Mickaël Ploquin, Urszula Eksmond, Rebecca Pike, Ulf Dittmer, Kim Hasenkrug, Marion Pepper and George Kassiotis. Clonotypic Composition of the CD4+ T Cell Response to a Vectored Retroviral Antigen Is Determined by Its Speed. Journal of Immunology, July 2014. 

Georgina Thorborn, George Young and George Kassiotis. J. Leuk. Bio. April 2014,  Effective T helper cell responses against retroviruses: are all clonotypes equal? Review.

Georgina Thorborn, Laura Pomeroy, Heidi Ishohanni, Barry S Peters & Annapurna Vyakarnam. Eur J Immunol. January. 2012. Elevated effector cell sensitivity to Treg suppression that is not associated with reduced Th17 expression distinguishes HIV+ asymptomatic subjects from progressor.

Raymond A Alvarez, Georgina Thorborn, James L Reading, Shalini KamuReddyr and Annapurna Vyakarnam. Retrovirology, May 2011. WFDC1/ps20 is a novel host factor that renders CD4 T-lymphocytes vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions.

Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, Melissa Perry, Barry Peters, Annapurna Vyakarnam. PLoS ONE: February 2010. Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection.

In preparation previous laboratory: 

Does WFDC1/ps20 expression in CD4 T cells identify a novel regulatory cell phenotype?
Thorborn G., Scotta, C., Gudivada, R., Reddy, S., Reading, J., Alvarez R., Hickman O., Smith, RAG., Tree, T., Lombardi, G. & Vyakarnam, A.

Selected poster presentations:

Georgina Thorborn & George Kassiotis, Adenovirus 5-vectored retroviral antigens uniquely elicit low-affinity T cell responses, Keystone Symposium on: HIV vaccines Adaptive Immunity and Beyond  (X3) and HIV Pathogenesis- Virus vs Host (X4). Banff, Canada. March 2014 (P2010). 

Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, & Annapurna Vyakarnam, Barry Peters, Elevated Treg-mediated Suppressive Potential, but Not Treg:IL-17 Ratio Distinguishes Chronic Asymptomatic Treatment-naïve HIV+ Subjects from Patients Who Progress to Disease, CROI, Boston February 2011 (P263).

Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, Melissa Perry & Annapurna Vyakarnam, Barry Peters, Novel evidence that enhanced quality of CD4 T regulatory cell function rather than quantity is associated with virus control in HIV, BHIVA Conference, Manchester, 23rd April 2010 (P57). 

Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, Barry Peters & Annapurna Vyakarnam, Novel evidence that enhanced quality of CD4 T regulatory cell function rather than quantity is associated with virus control in HIV-1 infection, Keystone Symposium on: Prevention of HIV/AIDS (X4) and HIV Immunobiology (X3). Keystone Co, USA. March 2009.

 

 

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