Post-Doctoral Arthritis Research UK Fellow
Summary of Research
Dr Elisa Corsiero is a post-doctoral Arthritis Research UK Fellow of the Immuno-Rheumatology group led by Dr Michele Bombardieri within the Centre of Experimental Medicine and Rheumatology. She graduated from University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009 she joined the group of Professor Costantino Pitzalis at the Centre for Experimental Medicine & Rheumatology. During her PhD, she generated recombinant monoclonal antibodies from naïve and memory B cells obtained from peripheral blood of SS patients and from single CD19+ B cells isolated from the synovial tissue obtained from joint replacements of RA patients with anti-citrullinated proteins antibodies. Using this approach, she provided original evidence that: i) patients with SS display accumulation of autoreactive IgD+ circulating naïve B cells, demonstrating the presence of impaired tolerance checkpoints in the early stages of B cell development in SS; ii) B cell clones, diversified and affinity-matured within the joints of RA patients, strongly react with neutrophils extracellular traps (NETs). In 2014 she was awarded an Arthritis Research UK Foundation Fellowship.
Her research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single RA synovial B cells.
Members of the Group
Dr Lucas Jagemann (Research Assistant)
Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. E Corsiero, M Bombardieri, E Carlotti, F Pratesi, WH Robinson, P Migliorini, and C Pitzalis. Ann Rheum Dis. 2015 Dec 9. pii: annrheumdis-2015-208356. doi: 10.1136/annrheumdis-2015-208356.
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Sarah E. Headland, Hefin R. Jones, Lucy V. Norling, Andrew Kim, Patricia R. Souza, Elisa Corsiero, Cristiane D. Gil, Alessandra Nerviani, Francesco Dell’Accio, Costantino Pitzalis, Sonia M. Oliani, Lily Y. Jan, Mauro Perretti. Science Translational Medicine. 11/2015; 7(315). DOI:10.1126/scitranslmed.aac5608
Accumulation of Self-Reactive Naive and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjogren's Syndrome. E Corsiero, N Sutcliffe, C Pitzalis, M Bombardieri. PlosOne. 2014;9(12):e114575.
Ectopic Lymphoid Structures: Powerhouse of Autoimmunity. E Corsiero, A Nerviani, M Bombardieri, C Pitzalis. Front. Immunol., 17 October 2016 http://dx.doi.org/10.3389/fimmu.2016.00430
NETosis as source of autoantigens in rheumatoid arthritis. E Corsiero, F Pratesi, E Prediletto, M Bombardieri, P Migliorini Review, Front. Immunol. - Molecular Innate Immunity DOI: 10.3389/fimmu.2016.00485
Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis. E Corsiero, C Pitzalis and M Bombardieri. Drug Discovery Today. 2014 May 28. pii: S1359-6446(14)00224-4.
Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. E Corsiero, M Bombardieri, A Manzo, S Bugatti, M Uguccioni and C Pitzalis. Immunology Letters 2012 Jul 30; 145(1-2):62-7.