Pearse, Rupert

NIHR Professor of Intensive Care Medicine

Rupert Pearse graduated in 1996 from St  George’s Hospital Medical School, London,  UK. He also completed much of his clinical training in the south-west Thames region.   His clinical duties are based on the busy Adult Critical Care Unit at the Royal London Hospital where he oversees the care of various groups of critically ill patients including trauma, stroke, infection and  major surgery. In 2006, Rupert was appointed Senior Lecturer in Intensive Care Medicine at Queen Mary, University of London and was promoted to Professor in 2014. He is an active member of several national and international societies for anaesthesia and intensive care medicine. He teaches both undergraduate and postgraduate students. He leads the Critical Care and Perioperative Medicine Research Group. Rupert’s main research interests are in improving outcomes for patients following major surgery and the cardiovascular pathophysiology of critical illness. Rupert plays a leading role in many large multi-centre studies including ISOS, PRISM and EPOCH. He has experience in a wide range of research methods including translational laboratory and clinical research, multi-centre observational and randomised trials and large epidemiological studies.

Summary of Research

Our research is primarily centred around the care of patients who have developed acute life threatening (critical) illness, or who may be at risk of this. This includes patients undergoing major surgery, patients with severe infection, and victims of major trauma. We see acute illness not only as an immediate threat to life, but also as a cause of important deterioration in patients’ long-term health through deteriorations in long-term diseases including kidney disease and heart failure. We are also researching new ways to improve healthcare and the long-term outlook for these patients, to improve short-term survival as well as long-term health.



Members of the Group

Ana Gutierrez

Ana Gutierrez del Arroyo
Ana is a Senior Postdoctoral Research Fellow.  She obtained her PhD in 2000 in Biochemistry and Molecular Biology at University Autonoma, Madrid. This explored the mechanism of p53-induced apoptosis in lymphocytes and the use of chemotherapeutic drugs in cancer treatments. Postdoctoral work includes cellular senescence and cell cycle regulation at London Cancer Research Institute (former ICRF; Gordon Peters laboratory); mechanisms of Myeloproliferative disorders and Sepsis Induced Immunoparesis at UCL, and organ dysfunction perioperative Medicine at UCL/QMUL.


Key Publications

For a full list of publications click here

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014; 311: 2181-90.

Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM.  Incidence of postoperative death and acute kidney injury associated with i.v. 6 hydroxyethyl starch use: systematic review and meta-analysis. Brit J Anaesth. 2014; 112: 25-34.

Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L, Hoeft A, Rhodes A, et al. Mortality after surgery in Europe: a 7 day cohort study. The Lancet. 2012; 380: 1059-1065

VISION Study Investigators, Devereaux PJ, Chan M, Alonso-Coello P, Walsh M, Berwanger O, Villar J, Wang C, Garutti R, Jacka M, Sigamani A, Srinathan S, Biccard B, Chow C, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels-Ansdell D, Sessler D, Thorlund K, Garg A, Mrkobrada M, Thomas S, Rodseth R, Pearse RM, Thabane L, McQueen M, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S. Association between postoperative troponin levels and 30-day mortality among patients undergoing non-cardiac surgery.  JAMA. 2012; 307: 2295-304

Pearse RM, Ackland GL. Perioperative fluid therapy.  BMJ. 2012; 344: e2865

Pearse RM, Holt PJ, Grocott MP. Managing perioperative risk in patientsundergoing elective non-cardiac surgery. BMJ. 2011; 343: d5759

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM. Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial.Crit. Care.  2010; 14(4): R151

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