Barts Health NHS Trust Honorary Senior Lecturer in Paediatric Endocrinology
I joined Barts Health NHS Trust and William Harvey Research Institute in 2013. I am a Paediatric Endocrinologist, practicing in The Royal London Hospital - Barts Health NHS Trust, as well as outreach clinics in Newham Hospital, Whipp’s Cross Hospital, Basildon and Thurrock Hospital and Broomfield Hospital, and as a Senior Lecturer in Paediatric Endocrinology in the William Harvey Research Institute. I was clinically trained in Paediatrics and Paediatric Endocrinology in both The Netherlands (Sophia Children’s Hospital, Rotterdam) and the UK (Great Ormond Street Hospital, London). My PhD was performed in the National Institute for Medical Research (Mill Hill, London) and in Leiden University Medical Centre, The Netherlands, and my post-doctoral research in the National Institute for Medical Research. I am currently building up my group in The William Harvey Research Institute.
Summary of Research
My main interests are pituitary disorders, including congenital hypopituitarism and craniopharyngioma, neuroendocrinology and growth disorders. I have worked in the field of Paediatric Endocrinology since 1992 both clinically and in basic science. My work has focused on GH-Stat5-IGF1 axis and the physiology of growth and short stature, both in rodents and in humans, looking at GH secretion, GH receptors and GH signalling transduction through Stat5, and local actions of GH and IGF1 in the growth plate where actual growth takes place.My current research focuses on underlying genetic causes for hypopituitarism, craniopharyngioma and short stature, and the biological consequences of such genetic abnormalities. The aim of my research is to:
1. Increase our understanding of the physiology of the pituitary – growth plate axis and the pathology of craniopharyngioma
2. Correctly diagnose children with pituitary and growth disorders
3. Shorten the time between presentation and diagnosis
4. Offer and develop individualised treatment that is rational for the underlying genetic disorder.
I form a clinician scientist – basic scientist partnership with Dr Carles Gaston-Massuet in the William Harvey Research Institute. I currently co-supervise a PhD student with Dr Carles Gaston-Massuet (Dr Nikolina Kyprianou) in a project on pituitary tumors and craniopharyngioma, I am the Principle Investigator in a study in collaboration with Prof Dattani, Dr Vivian Hwa, and Dr Lou Metherell on genetic underlying causes of short stature, and am a Principle Investigator in clinical and observational studies for Type 2 Diabetes and Growth Hormone treatment.
Internal: Dr Carles Gaston-Massuet, Dr Lou Metherell, Dr Helen Storr.
External: Prof Mehul Dattani and Prof Peter Hindmarsh (Great Ormond Street Hospital / Institute of Child Health, London), Prof Chatterjee, Dr Nadia Schoenmakers and Dr Carla Moran (Addenbrooke’s Hospital / Institute of Metabolic Sciences, Cambridge), Dr Vivian Hwa (Cincinnati Children’s Hospital, Cincinnati, US), Dr Tim Wells (Institute of Biosciences, Cardiff), Dr Edward Visser Erasmus MC (Rotterdam, The Netherlands).