Charles Johnston Hinds

Charles J Hinds

Professor (emeritus) / Consultant in Intensive Care Medicine

Charles Hinds qualified at St. Bartholomew’s Hospital in 1972 and was appointed as Consultant and Senior Lecturer in Anaesthesia and Intensive Care at the same hospital in 1980. Subsequently he was Director of the Intensive Unit at Barts, and later for the combined Barts and The London NHS Trust, for more than 15 years. He is a past President of the Intensive Care Society and was Chairman of Examiners for the UK Diploma of Intensive Care. He was UK Representative for the European Society of Intensive Care Medicine and a member of the Education and Training Subcommittee of the ESICM. He was for many years a member of the Research Committee of the Intensive Care Society. In January 2007 Professor Hinds was awarded a College Medal by the Royal College of Anaesthetists as a mark of distinction for his work in helping the College to achieve its aims and for his support for the speciality. He was subsequently invited to deliver the Samuel Thompson Rowling oration at the College. In 2013 Prof. Hinds was awarded Honorary Lifetime Memberships of the ESICM and UK Intensive Care Society. Together with Prof. Watson, Professor Hinds has published three editions of their popular textbook: Intensive Care: A concise textbook.

Summary of Research

Professor Hinds’ research interests have included the pathophysiology and treatment of sepsis, “goal directed” haemodynamic therapy, endocrine aspects of critical illness, critical illness polyneuromyopathy and intensive care for patients with malignancy. In the last decade he has developed an interest in the genomics of sepsis and has helped to establish the UK Critical Care Genomics Group which is undertaking a large National investigation (GAinS), as well as being National co-ordinator for the European “GenOSept” study (ESICM). Other current research interests include improving outcomes for patients undergoing high-risk surgery.

Memberships / Awards

Honorary Lifetime Member of the European Society of Intensive Care Medicine and the UK Intensive Care Society.

Teaching 

SSCs in Intensive Care. Dissertation SSCs.

 

Members of the Group

  • Professor Rupert Pearse
  • Professor Gareth Ackland
  • Professor David Watson
  • Professor Mark Griffiths
  • Dr Michael O’Dwyer
  • Dr John Prowle

Key Publications

For a full list of publist publications click here.

Hayes MA, Timmins AC, Yau EHS, Palazzo M, Hinds CJ, Watson JD.  Elevation of systemic oxygen delivery in the treatment of critically ill patients. New Engl J Med 1994; 330: 1717-1722.

Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, Hinds CJ. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 1999; 341: 785-792.

Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, McDermott MF, Millo JL, Welsh KI, Holloway P, Hitman GA, Piper RD, Garrard CS, Hinds CJ. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes and Immunity 2004; 5: 631-640.

Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P, Verheij T, Garrard CS, Hinds CJ, Goossens H, Chapman S, Hill AVS. IFITM3 and susceptibility to respiratory viral infections in the community. Journal of Infectious Diseases 2014; 209: 1028-1031.

Jesmond Dalli, Lucy V Norling, Trinidad Montero-Melendez, Donata F Canova, Hazem Lashin, Anton M Pavlov, Gleb B Sukhorukov, Charles J Hinds & Mauro Perretti. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Molecular Medicine 2014; 6: 27-42.

Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PAH, Chiche J-D, Bion J, Stuber F, Garrard C, Hinds C and the GenOSept Investigators. Patients with faecal peritonitis admitted to European Intensive Care Units: An epidemiological survey of the GenOSept cohort. Intensive Care Medicine 2014; 40: 202-210.

Walden AP, Clarke GM, McKechnie S, Hutton P, Gordon AC, Rello J, Chiche J-D, Stuber F, Garrard CS, Hinds CJ. Patients with community-acquired pneumonia admitted to European Intensive Care Units: an epidemiological survey of the GenOSept cohort. Critical Care 2014; 18: R58.

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured Polytrauma Patients. Annals of Surgery 2014;

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocoss MPW, Ahern A, Griggs K, Scott R, Hinds CJ, Rowan K for the OPTIMISE study group. Effect of a peri-operative, cardiac output-guided, hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: A multi-center randomized controlled trial. JAMA 2014; doi:10.1001/jama.2014.5052.

Rauntanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche J-D, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri M, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider M, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stuber F, Hill ADS, Hinds CJ for the ESICM/ECCRN GenOSept Investigators. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respiratory Medicine 2015; 3: 53-60.

Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche J-D, Holloway PAH, Stuber F, Garrard CS, Hinds CJ, Hill AVS, Rautanen A for the ESICM/ECCRN GenOSept Investigators. Variants in the mannose-binding lectin gene MBL2 do not associate with sepsis susceptibility or survival in a large European cohort. Clinical Infectious Diseases 2015; on-line.

Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AVS, Hinds CJ, Knight JC. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respiratory Medicine 2016; 4: 259-71

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