O'Dwyer, Michael

Michael O'Dwyer

Adult Critical Care Unit

Dr O’Dwyer graduated from medical school at Trinity College, Dublin, Ireland in 1998 and then subsequently trained and specialised as an anaesthetist. In 2008 he acquired his PhD, again from Trinity College, which explored the innate and adaptive immune response to human infection and critical illness. He also developed a research interest in high altitude physiology and was a member of the 2007 xtreme everest expedition acquiring arterial blood samples from the summit of Mt Everest.  A further period of clinical training led to a second specialisation as an intensive care medicine physician in Australia. Following this, he was appointed in 2012 as a Senior Lecturer in Intensive Care Medicine at QMUL and an honorary ICU consultant at The Royal London Hospital.

Summary of Research

  • Immunological, genetic and epigenetic factors in the susceptibility to develop hospital-acquired infections in critically ill patients
  • T cell maturation and the susceptibility to develop hospital-acquired infections following elective major surgery
  • Gene expression following uneventful cardiac surgery
  • Inflammatory and immune mediators in high altitude performance.

Members of the Group

Research staff: Helen Owen, Hew Torrance, Rebecca Longbottom, James O'Carroll

Key Publications

For a full list of publist publications click here

Torrance HDT, Vivian M, Brohi K, Pearse RM, Owen HC, Hinds CJ, O’Dwyer MJ. The duration of storage of packed red blood cells prior to transfusion is associated with a characteristic gene expression pattern. J Trauma Acute Care Surg. 2014 In press.

Fragou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O’Dwyer MJ. Perioperative blood transfusion is assocaited with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Crit Care 2014. Oct 1;18(5):541 

Torrance HDT, Brohi K, Pearse R, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Ann Surg 2014 Mar 25.

McMorrow RCN, Windsor JS, Hart ND et al. (2012). Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). ANAESTHESIA Vol.67, (8) 0003-2409 875-880.
10.1111/j.1365-2044.2012.07152.x
 
White M, Martin-Loeches I, Lawless MW et al. (2011). Hospital-Acquired Pneumonia After Lung Resection Surgery Is Associated With Characteristic Cytokine Gene Expression. CHEST Vol.139, (3) 0012-3692 626-632.
10.1378/chest.10-0016
 
White M, O'Dwyer M, Grealy R et al. (2009). INTERLEUKIN 6 PROTEIN EXPRESSION IN HUMAN HOST RESPONSE TO INFECTION AND SEPSIS DISPLAYS DISTINCTIVE PROFILES. CRITICAL CARE MEDICINE Vol.37, (12) 0090-3493 A214-A214.
 
White M, Grealy R, Lawless MW et al. (2009). APOPTOSIS MARKERS BIM AND BCL2 MRNA TRANSCRIPTION IN PERIPHERAL BLOOD MONONUCLEAR CELLS CAN DISTINGUISH BETWEEN THE HUMAN HOST RESPONSE IN INFECTION AND SEPSIS. INTENSIVE CARE MEDICINE Vol.35, () 0342-4642 168-168.
 
White M, Grealy R, O'Dwyer M et al. (2008). IL1 beta AND IL17 GENE TRANSCRIPTION AND PROTEIN EXPRESSION IN HUMAN RESPONSE TO INFECTION.. CRITICAL CARE MEDICINE Vol.36, (12) 0090-3493 A30-A30.
 
O'Dwyer MJ, Mankan AK, Ryan AW et al. (2008). Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis. INTERNATIONAL JOURNAL OF IMMUNOGENETICS Vol.35, (4-5) 1744-3121 279-285.
10.1111/j.1744-313X.2008.00773.x
 
Lawless MW, White M, Mankan AK et al. (2007). Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis. TISSUE ANTIGENS Vol.70, (4) 0001-2815 294-300.
10.1111/j.1399-0039.2007.00895.x
 
Duggan E, Caraher E, Gately K et al. (2006). Tumor necrosis factor-alpha and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery. CRITICAL CARE MEDICINE Vol.34, (8) 0090-3493 2134-2139.
10.1097/01.CCM.0000227647.77356.AB

National Institute of Academic Anaesthesia

Internal: Prof Charles Hinds (WHRI); Prof Karim Brohi (Blizzard Institute); Dr Rupert Pearse (Intensive Care Medicine).

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